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High-Frequency Deep Brain Stimulation of the Putamen Improves Bradykinesia in Parkinson's Disease

Identifieur interne : 001883 ( Main/Exploration ); précédent : 001882; suivant : 001884

High-Frequency Deep Brain Stimulation of the Putamen Improves Bradykinesia in Parkinson's Disease

Auteurs : Erwin B. Jr Montgomery [États-Unis] ; HE HUANG [États-Unis] ; Harrison C. Walker [États-Unis] ; Barton L. Guthrie [États-Unis] ; Ray L. Watts [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2011.

RBID : Pascal:11-0481761

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Haute fréquence, Putamen, Physiologie, Physiopathologie, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, High frequency, Nervous system diseases, Parkinson disease, Pathophysiology, Physiology, Putamen.

Abstract

Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high-frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no-stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High-frequency deep brain stimulation of the putamen improves bradykinesia in a hand-opening and -closing task in patients with Parkinson's disease. Consequently, high-frequency deep brain stimulation of virtually every structure in the basal ganglia-thalamic-cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation is effective for a wide range of neurological disorders; however, its mechanisms of action remain unclear. With respect to Parkinson's disease, the existence of multiple effective targets suggests that putamen stimulation also may be effective and raises questions as to the mechanisms of action. Are there as many mechanisms of action as there are effective targets or some single or small set of mechanisms common to all effective targets? During the course of routine surgery of the globus pallidus interna in patients with Parkinson's disease, the deep brain stimulation lead was placed in the putamen en route to the globus pallidus interna. Recordings of hand opening and closing during high-frequency and no stimulation were made. Speed of the movements, based on the amplitude and frequency of the repetitive hand movements as well as the decay in amplitude, were studied. Hand speed in 6 subjects was statistically significantly faster during active deep brain stimulation than the no-stimulation condition. There were no statistically significant differences in decay in the amplitude of hand movements. High-frequency deep brain stimulation of the putamen improves bradykinesia in a hand-opening and -closing task in patients with Parkinson's disease. Consequently, high-frequency deep brain stimulation of virtually every structure in the basal ganglia-thalamic-cortical system improves bradykinesia. These observations, together with microelectrode recordings reported in the literature, argue that deep brain stimulation effects may be system specific and not structure specific.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

High-Frequency Deep Brain Stimulation of the Putamen Improves Bradykinesia in Parkinson's Disease

High-Frequency Deep Brain Stimulation of the Putamen Improves Bradykinesia in Parkinson's Disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri